Dr. Timir Tripathi

Molecular and Structural Biophysics Laboratory

Publications

29. Vimal, A., Pal, D., Tripathi, T*, and Kumar, A. Eucalyptol, sabinene and cinnamaldehyde: potent inhibitors of Salmonella target protein l-asparaginase. 3Biotech. 2017, 7:258.

28. Shukla, H., Shukla, R., Sonkar, A. and Tripathi, T*. Alterations in conformational topology and interaction dynamics caused by L418A mutation leads to activity loss of Mycobacterium tuberculosis isocitrate lyase. Biochem Biophys Res Commun. 2017, 490(2); 276-282.

27. Shukla, R., Shukla, H., Kalita, P., Sonkar, A., Pandey, T., Singh, D.B., Kumar, A. and Tripathi, T*. Identification of potential inhibitors of Fasciola gigantica thioredoxin1: Computational screening, molecular dynamics simulation and binding free energy studies. J Biomol Struct Dyn. 2017, doi.10.1080/07391102.2017.1344141. 

26. Shukla, R., Shukla, H., Sonkar, A., Pandey, T. and Tripathi, T*. Structure-based screening and molecular dynamics simulations offer novel natural compounds as potential inhibitors of Mycobacterium tuberculosis isocitrate lyase. J Biomol Struct Dyn. 2017, doi.10.1080/07391102.2017.1341337.

25. Shukla, H., Kumar, R., Sonkar, A., Mitra, K., Akhtar, M.S. and Tripathi, T*. Salt-regulated reversible fibrillation of Mycobacterium tuberculosis isocitrate lyase: Concurrent restoration of structure and activity. Int J Biol Macromol. 2017, 104; 89-96.

24. Shukla, H., Shukla, R., Sonkar, A., Pandey, T. and Tripathi, T*. Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility. Sci Rep. 2017, 7, 1058; doi.10.1038/s41598-017-01235-z.

23. Sonkar, A., Shukla, H., Shukla, R., Kalita, J., Pandey, T. and Tripathi, T*. UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) of Acinetobacter baumannii (AbMurA): Structural and functional properties. Int J Biol Macromol. 2017, 97; 106-114.

22. Pandey, T., Shukla, R., Shukla, H., Sonkar, A., Tripathi, T* and Singh, A.K. A combined biochemical and computational studies of the rho-class glutathione s-transferase sll1545 of Synechocystis PCC 6803. Int J Biol Macromol. 2017, 94; 378-385.

21. Tripathi, T*, Suttiprapa, S. and Sripa, B. Unusual thiol-based redox metabolism of parasitic flukes. Parasitol Int. 2017, 66; 390-395.

20. Gupta, A., Sripa, B. and Tripathi, T*. Purification and characterization of a two-domain glutaredoxin in the parasitic helminth Fasciola gigantica. Parasitol Int. 2017, 66; 432-435.

19. Bharati, A.P., Singh, N., Kumar, V., Kashif, M., Singh, A.K., Singh, P., Singh, S.K., Siddiqui, M.I., Tripathi, T. and Akhtar, M.S. The mRNA capping enzyme of Saccharomyces cerevisiae has dual specificity to interact with CTD of RNA Polymerase II. Sci Rep. 2016, 6; 31294. doi.10.1038/srep31294.

18. Gupta, A., Kesherwani, M., Velmurugan, D. and Tripathi, T*. Fasciola gigantica thioredoxin glutathione reductase: Biochemical properties and structural modeling. Int J Biol Macromol. 2016, 89, 152-160.

17. Nisha, C.M., Kumar, A., Nair, P., Gupta, N., Silakari, C., Tripathi, T*. and Kumar A. Molecular docking and in silico ADMET study reveals acylguanidine 7a as a potential inhibitor of β-secretase. Adv Bioinformatics 2106, 9258578. doi:10.1155/2016/9258578. 

16. Kumar, A., Nisha, C.M., Silakari, C., Sharma, I., Anusha, K., Gupta, N., Nair, P., Tripathi, T. and Kumar A. Current and novel therapeutic molecules and targets in Alzheimer’s disease. J Formos Med Assoc2016, 115, 3-10. 

15. Gupta, A., Kumar, B., Pandey, T. and Tripathi, T*. Preferential regeneration of thioredoxin from parasitic flatworm Fasciola gigantica using glutathione system. Int J Biol Macromol. 2015, 81, 983-990.

14. Chhetri, G., Kalita, P. and Tripathi, T*An efficient protocol to enhance recombinant protein expression using ethanol in Escherichia coli.MethodsX 2015, 2, 385-391.

13. Chhetri, G., Pandey, T., Chinta, R., Kumar, A and Tripathi, T*. An improved method for high-level soluble expression and purification of recombinant amyloid-beta peptide for in vitro studies. Protein Expres Purif. 2015, 114, 71-76. Link

12. Pandey, T., Singh, S.K., Chhetri, G., Tripathi, T* and Singh, A.K. Characterization of a highly pH Stable Chi-Class glutathione S-transferase from Synechocystis PCC 6803. PLoS One. 2015, 10(5):e0126811. 

11. Vijayakumar, R., Kalita, P., and Tripathi, T*. Fascioliasis and food safety. In Neglected Tropical Diseases and Food Safety. Omics Group Int. 2015, (In Press). 

10. Tripathi, T*. The N-terminal portion of the glutaredoxin like protein 1 of Plasmodium falciparum does not contribute to the stability of the enzyme. J Protein Proteomics. 2015, 6(2), 153-158. Link

9. Pandey, T., Chhetri. G., Chinta, R., Kumar. B., Singh, D.B., Tripathi, T* and Singh, A.K. Functional classification and biochemical characterization of a novel rho class glutathione S-transferase in Synechocystis PCC 6803. FEBS Open Bio. 2015, 5, 1-7. Link

8. Chhetri. G., Pandey, T., Kumar. B., Akhtar, M.S. and Tripathi, T*. Recombinant expression, purification and preliminary characterization of the mRNA export factor MEX67 of Saccharomyces cerevisiae. Protein Expres Purif. 2015, 107, 56-61. Link

7. Chhetri. G., Ghosh. A., Chinta. R., Akhtar, M.S. and Tripathi, T*. Cloning, soluble expression, and purification of the RNA polymerase II subunit RPB5 from Saccharomyces cerevisiae. Bioengineered. 2015, 6:1, 1-5. Link

6. Yogavel, M., Tripathi, T., Gupta, A., Bandey, M.M., Rahlfs, S., Becker, K., Belrhali, H. and Sharma, A. (2014) Atomic-resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other GrxsActa Crystallogr., Sect. D: Biol. Crystallogr. 70; 91-100.  Link

5. Tripathi, T* (2013) Calculation of thermodynamic parameters of protein unfolding using far-ultraviolet circular dichroism: A Review.  J Proteins Proteomics 4(2); 85-91. Link

4. Tripathi, T., Roseler, A., Rahlfs, S., Becker, K., and Bhakuni, V. (2010) Conformational stability and energetics of Plasmodium falciparum glutaredoxin. Biochimie. 92, (3):284-291. Link

3. Tripathi, T., Na, B.K., Sohn, W.M., Becker, K., and Bhakuni, V. (2009). Structural, functional and unfolding characteristics of glutathione S-transferase of Plasmodium vivax. Arch. Biochem. Biophys. 487, 115–122. Link

2. Tripathi, T., Rahlfs, S., Becker, K. and Bhakuni, V. (2008) Structural and unfolding characteristics of a monothiol glutaredoxin: Glutaredoxin like protein 1 from Plasmodium falciparum. Biochim. Biophys. Acta 1784, 946-952. Link

1. Tripathi, T., Rahlfs, S., Becker, K. and Bhakuni, V. (2007) Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase. BMC Struct. Biol. 7, 67. Link

 

* Corresponding Author