Research interest: Structure-function-folding-flexibility-dynamics relationship of proteins using biochemistry, molecular biology, biophysics, and computational approaches.
Our laboratory is working on three broad areas:
- The characterization of enzymes of chemotherapeutic importance for structure based drug development. We target two major protein systems: 1) Thiol-based redox-active proteins, and 2) Aminoacyl tRNA-synthetases.
- Understanding mRNA export by studying the novel interacting partners of mRNA export factor, Mex67 in yeast.
- Inhibition of β-amyloid fibrillation using plasmapheresis, where we target Transferrin.